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pentobarbital will reduce the extent or result of fedratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Impact of coadministering a robust CYP3A4 inducer with fedratinib has not been studied.pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism.